Wait, Wait, Don’t Tell Me!—A silly quiz show where people make fun of current news stories.
Le Show—Harry Shearer (aka Mr. Burns from The Simpsons/Derek Smalls from Spinal Tap) takes a rather scathing look at the week’s news. (He really hates Rupert Murdoch and the Army Corps of Engineers, BTW.)
RadioLab—A rather eclectic single topic show, which examines things in art, science, technology, etc. One of the hosts just one a MacArthur Genius Grant.
Hearing Voices—A similar style of show, with less formal narration.
99% Invisible—Its a show about architecture and design.
Science Friday—The title pretty much explains it all.
Freakonomics Podcast— The authors of the books with the same name discuss a wide range of topics from an economist’s point of view. Way more interesting than you might think.
Tech News Today—A discussion of technology stories which have broken in the past 24 hours or so.
The Infinite Monkey Cage—Demonstrates what happens when you put together a panel consisting of a stand up comic, top people in a given scientific field, and a studio audience.
This Week in Tech—Leo Laporte and others discuss tech news of the past week. Covers some of the same ground as the above mentioned TNT, but with different folks, a longer run time, and has digressions into things far outside of tech (like wine).
Science in Action—One of the many BBC science podcasts. This is a weekly program, which covers current news.
Discovery—Another BBC science podcast. This one is a single topic podcast and covers things you’re unlikely to hear on other podcasts. (For example, the multi-part series titled Thin Air talked about Europe’s version of HAARP.)
Dr Karl and the Naked Scientist—In the US people call into ‘tards on C2C, in the UK, they call in and talked to scientists.
Click—A consumer (though not strictly limited to such) tech podcast from the BBC.
The Guardian’s Science Weekly Podcast—The UK’s Guardian newspaper’s science podcast
Skeptoid—Taking a skeptical look at things like the Loch Ness Monster.
MacBreak Weekly—An Apple centric podcast from the TWiT Network.
Windows Weekly—A Microsoft centric podcast from the TWiT Network.
Android Central—More than you ever wanted to know about Android.
BBC Focus Magazine—This is a mix of things like hard science and new technology like the latest iPhone or what have you.
Weekly Daily Giz Wiz—Mad Magazine’s Dick DeBartolo and Leo Laporte share their favorite new gadgets, as well as one dud of a gadget from the past.
Nature—Podcast of the science journal Nature
PRI’s The World: Technology—An interesting look at how technology is changing the lives of people around the world. This isn’t about how cool the newest iPhone/Android device, etc., is, but what people are doing with them.
Science Magazine—Podcast from the American Academy for the Advancement of Science
Science Talk—Podcast of Scientific American
Science Update—Another AAAS podcast
Security Now—A discussion of current computer security news. Can be dull as hell sometimes, but other times, you’ll wind up shitting your pants from fear.
This Week in Google—A panel discussion of the latest news about Google, Facebook, and similar online services.
Tree Hugger Radio—Environmental News
Slice of SciFi—Dedicated to keeping you up to date on what’s happening in science fiction. Has a weekly feedback show which generally will have you pissing in your pants with laughter at some of the comments. (“Chewie had bitch tits.”)
Relic Radio Science Fiction—Classic science fiction radio programs from the English speaking world.
Scifi Friday—Plays some of the same classic SF programs as the above, but has some different ones as well.
Current Geek—This is just what the hosts think is the “Nerdiest Story of the Week.” It could be something related to science fiction, or it might just be a new science breakthrough or an impressive piece of technology.
Frame Rate—This deals with movies, TV, books, and online video, mostly aimed at SF, but other things as well (they’ll have discussions of Breaking Bad along with Walking Dead, for example.)
Old Time Radio SciFi—A mix of old radio serials from the 30s to the 70s. It has some of the same programs as the others, but different ones as well.
sciFi Old Time Radio—A mix of old radio serials from the 30s to the 70s. It has some of the same programs as the others, but different ones as well.
X Minus One—A SF anthology radio program from the 1950s.
Zero Hour—An anthology radio program from the 70s hosted by Rod Serling. Most of the episodes are suspense/murder mystery, but a few are SF/horror.
Old Time Radio Adventures—A grab bag of radio serials from the 30s to the 70s. A few SF ones, as well as a mix from a number of other genres. You never really know what you’re going to get.
Archaeology Channel—News of some of the latest archaeological discoveries.
History Extra—BBC’s History Magazine’s podcast. Tends to have a UK bent, but will talk about other things as well.
Pritzker Military Library Podcasts—Primarily focused on US military history and most of the podcasts are one hour lectures by authors promoting their current work, but well worth a listen if the subject is even remotely interesting to you.
Stone Pages—Concentrates on Stone Age archaeological news, and is hosted by someone who does field work, so you get a rather interesting perspective on things.
Point of Inquiry—A podcast from the Center of Inquiry, and while primarily focused on atheism, they often do have religious folks on who firmly believe in the separation of church and state as outlined in the US Constitution.
American Freethought Podcast—All atheism, all the time.
Ask an Atheist—A radio talk show about atheism.
Living After Faith—Interviews and discussions about what its like to no longer be religious.
NASA has a metric buttload of audio and video podcasts covering manned and unmanned missions as well as environmental news and much more.
Librivox—Volunteers read books in the public domain. You won’t find any of the latest best sellers here, but if you’re looking for a first person account of the Civil War, WWI or any number of things, as well as literature, and other writings 50+ years old, this is a good place to check. (Lots of stuff by the Founding Fathers.) The quality of the readers varies wildly, but some of them do work for Audible as well.
Magnatune—They’re a small record label which puts out podcasts that contain samples of the various artists on their label. While its doubtful that you’ll have heard of any of their artists in things like rock and roll, they do cover every genre of music you can think of, from classical, non-Western, and various modern genres as well. Undoubtedly you can find something you like well enough to have as background noise. Beats things like Pandora and similar web services as you don’t have to worry that some generic tune which you can hear on any over the air radio station will show up in your feed.[