In what respect? Do you mean in terms of nationalism or territory?
In general structures. Compare Mediæval Europe with what we know about the Americas and you see alot more rigidity and authoritarianism in structure. Even the Aztecs barely reach their level in terms of centralized authority and barbarity. Slavery in the Aztec Empire was a form of punishment for severe crimes whereas slavery in Europe was a means of exploitation for a higher class.
Europe as a land mass is much smaller than the two American continents. Nothing like the Haudenosaunee existed anywhere in Europe at that time, and likewise, nothing like Mediæval Europe existed anywhere in the America’s. Even the Inca’s had some form of separation of powers that were not present in Europe.
Again, the closest that anyone can show were the Aztecs, but there were differences. You can definitely check the credibility of wikipedia for this source, I personally already have previously, but here are some of the differences they noted:
“Like most European empires, it was ethnically very diverse, but unlike most European empires, it was more a system of tribute than a single system of government.”
“Due to the steady surveillance, even women could travel alone, a fact that amazed the Spaniards, as that was not at all possible in Europe since the time of the Romans.”