Re: Vitamins - Natural Food Stores
[quote author=“jimmiekeyes”]Lately the Glucosamine Chondroitin formulations everyone but me took at a cost of over $50.00 a month have been tested in a double blind study.
The result was what I expected. In a word, they suck.
What do you all think of the use of vitiamins in large quantities? Or small quantities for that matter.
What do you think of the far eastern uses of dried ground animal parts like bear gall bladders? Do they have merit?
I think you and some of the others that cite QuackWatch need to be more critcal in your review of reviews, or in this case the Glucosamine “Study” that I think you are referring to.
The problem with the study stating that glucosamine did not show an improvement in symptoms is somewhat of a classic strawman set-up. First let’s define symptoms: Joint Pain. Pain is the symptom of Inflammation. Inflammation is the result of clinical osteoarthritis (OA) or bone on bone grinding on any joint surface.
Secondly, It should be noted that Glucosamine is NOT classified as any type of COX inhibitor or anti-inflammatory. Glucosamine by definition: Is an important building block needed by the body to manufacture specialized molecules called glycosaminoglycans, found in cartilage, Not a COX-2 inhibiting drug such as celecoxib (Celebrex). In essence, Glucosamine is only applicable in cases of OA ( “wear and tear” arthritis, the gradual, chronic joint disease that is primarily associated with aging and injury).
Quoting from the “Study”:
“The group of patients who took celecoxib did have a statistically significant improvement in their symptoms. These results suggest that glucosamine and chondroitin do not effectively relieve pain in osteoarthritis patients.”
This is an easy conclusion given the premise (if you want to call it that) is flawed is far from a sound argument. The comparison being made doesn’t even compare apples to apples (Cox-2 to Cox-2).
The study should have compared apples to apples, namely a Natural COX-2 Inhibitor such as standardized Boswellia Extract, Hops Extract (I like IsoOxygene) or Curcumin (Turmeric).
It should also be noted that Vioxx (Mercks Cox-2) and Celebrex carry Gastrointestinal & Cardiovascular ADRs (Adverse Drug Reactions). Is the risk worth the reward?
As with any treatment of OA, simply addressing inflammation is merely treating the symptom of pain. The underlying factor of worn joint cartilage should always be looked at too. Rebuilding joint cartilage is a process that takes many months to years to see (and feel) a difference. The process of building new joint cartilage in the knee for example does not happen over night, nor should it be expected to work overnight or in a short time-span. After-all, our knees take a beating from being on them for many years. Just think of all the weight bearing / jarring years the typical OA patient has seen in a lifetime….
Anyway, thats my two cents and is also my first message here. I love the podcasts for POI and look forward to a healthy debates about anything…
As for my recommendation, I like these two products. One is designed for Joint Support and has a form of glucosamine that I like plus a good natural COX-2 inhibitor (IsoOxygene) and other nutrients that have been shown to aid in the regeneration of cartilage.
The second product is mainly a straight COX-2 blend of botanicals but has some 5-LO inhibitors as well (another inflammatory pathway). This is called Inflacain.
Here is a copy of what I posted on another board here at CFI.