In addition to the unique advocacy the Center for Inquiry performs at the federal level, CFI also works with several national coalitions in order to accomplish shared goals. These groups consist of secular, civil rights, education, labor, and faith-based organizations:
- Coalition Against Religious Discrimination: works to fight President George W. Bush-era faith-based initiatives and taxpayer-funded religious discrimination.
- National Coalition for Public Education: works to prevent private and religious school voucher legislation in Congress.
- Coalition for Liberty and Justice: works to ensure that public policy protects the religious liberty of all individuals, and to oppose policies that impose one religious viewpoint on all.
- National Safe Schools Partnership: works to foster safe schools across America by addressing issues such as bullying and harassment in Congress.